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Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Dimensions of Health and Illness01:21

Dimensions of Health and Illness

The factors influencing the health-illness continuum can be internal or external and may or may not be under conscious control. They are related to the following eight human dimensions, and each dimension is interrelated to one other.
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Factors Affecting Illness01:18

Factors Affecting Illness

When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness, disability,...
Infectious Diseases and Their Occurrence01:28

Infectious Diseases and Their Occurrence

Infectious diseases appear in populations through various transmission patterns, influenced by pathogen characteristics, population immunity, environmental conditions, and social behavior. Understanding these patterns is essential for effective public health surveillance and intervention. These categories—sporadic, outbreak, epidemic, pandemic, and endemic—help frame the nature and scope of disease events.Sporadic diseases occur irregularly and infrequently, without a predictable temporal or...

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Related Experiment Video

Updated: May 25, 2026

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

Common variable immunodeficiency (CVID): exploring the multiple dimensions of a heterogeneous disease.

Ulrich Salzer1, Susanne Unger, Klaus Warnatz

  • 1Centre of Chronic Immunodeficiency, University Medical Centre Freiburg, Germany.

Annals of the New York Academy of Sciences
|February 4, 2012
PubMed
Summary

Common variable immunodeficiency (CVID) is a diverse antibody disorder with unclear causes. Recent advances are defining CVID into specific genetic and immunological subgroups for better understanding.

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Last Updated: May 25, 2026

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

Whole Blood Assay with Dual Co-Stimulation for Antigen-Specific Analysis of Host Immunity to Fungal and Viral Pathogens
06:03

Whole Blood Assay with Dual Co-Stimulation for Antigen-Specific Analysis of Host Immunity to Fungal and Viral Pathogens

Published on: September 20, 2024

Area of Science:

  • Immunology
  • Genetics
  • Human Diseases

Background:

  • Common variable immunodeficiency (CVID) is a heterogeneous group of antibody deficiencies.
  • CVID is characterized by diverse clinical features and largely undefined molecular causes.

Purpose of the Study:

  • To highlight recent developments in understanding Common variable immunodeficiency (CVID).
  • To focus on the genetic and immunological dimensions of CVID.

Main Methods:

  • Stratification of CVID patients into homogeneous subgroups.
  • Utilizing improved clinical and immunological criteria for patient classification.
  • Incorporating molecular, functional, immunohistological, and longitudinal data.

Main Results:

  • Increasing definition of CVID into single-gene and polygenic disorders.
  • Improved classification of CVID based on detailed patient data.
  • Emerging clarity on the genetic and immunological basis of CVID.

Conclusions:

  • Recent advancements are refining the classification of CVID.
  • Understanding the genetic and immunological aspects is key to defining CVID subtypes.
  • Further research will continue to unravel the complexities of CVID.