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Plasma BIN1 correlates with heart failure and predicts arrhythmia in patients with arrhythmogenic right ventricular

Ting-Ting Hong1, Rebecca Cogswell, Cynthia A James

  • 1Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94158, USA.

Heart Rhythm
|February 4, 2012
PubMed

Insights

Plasma Bridging Integrator 1 (BIN1) levels may indicate disease severity in arrhythmogenic right ventricular cardiomyopathy (ARVC). Lower BIN1 levels correlate with heart failure and predict future arrhythmias in ARVC patients.

Area of Science:

  • Cardiology
  • Biomarker Discovery
  • Molecular Cardiology

Background:

  • Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a progressive cardiac muscle disorder.
  • Bridging integrator 1 (BIN1) is crucial for cardiomyocyte health and is reduced in cardiomyopathy.
  • Investigating circulating BIN1 as a potential indicator of cardiac status in ARVC patients.

Purpose of the Study:

  • To assess plasma BIN1 levels as a measure of disease severity in ARVC patients.
  • To determine if BIN1 levels correlate with cardiac function and predict ventricular arrhythmias.

Main Methods:

  • Retrospective cohort study of 24 ARVC patients.
  • Assessed plasma BIN1 levels.
  • Correlated BIN1 levels with cardiac function and history of ventricular arrhythmias.

Main Results:

  • Plasma BIN1 levels were significantly lower in ARVC patients with heart failure compared to those without.
  • Lower BIN1 levels correlated with a higher number of previous ventricular arrhythmias.
  • Low BIN1 levels accurately predicted advanced heart failure and future ventricular arrhythmias (AUC 0.88-0.89).
  • Serial measurements showed decreasing BIN1 levels with disease progression.

Conclusions:

  • Plasma BIN1 levels correlate with cardiac functional status in ARVC.
  • BIN1 levels can predict the presence and future occurrence of ventricular arrhythmias.
  • Circulating BIN1 shows potential as a biomarker for ARVC severity and prognosis.
Abstract

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