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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
Regulation of the Cardiovascular System01:27

Regulation of the Cardiovascular System

The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...

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Related Experiment Video

Updated: May 25, 2026

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

microRNAs in cardiovascular development.

Jinghai Chen1, Da-Zhi Wang

  • 1Cardiovascular Research Division, Department of Cardiology, Children's Hospital Boston, Harvard Medical School, 320 Longwood Ave, Boston, MA 02115, USA.

Journal of Molecular and Cellular Cardiology
|February 4, 2012
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRNAs) are small RNAs crucial for heart development, acting as regulators to prevent congenital heart defects. Understanding their role offers new therapeutic avenues for cardiovascular diseases.

More Related Videos

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization
08:22

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Published on: September 15, 2018

Related Experiment Videos

Last Updated: May 25, 2026

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization
08:22

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Published on: September 15, 2018

Area of Science:

  • Cardiovascular Biology
  • Molecular Genetics
  • Developmental Biology

Background:

  • Precise gene expression regulation is vital for heart development.
  • Transcription factors control signaling pathways essential for cardiovascular formation.
  • Perturbations in cardiogenesis can lead to congenital heart defects and adult heart disease.

Purpose of the Study:

  • To review the roles of microRNAs (miRNAs) in cardiovascular development and function.
  • To explore the molecular mechanisms of miRNA action in maintaining cardiovascular homeostasis.
  • To propose potential therapeutic applications of miRNAs in cardiovascular diseases.

Main Methods:

  • Literature review of studies on miRNAs in cardiovascular development.
  • Analysis of molecular mechanisms involving post-transcriptional gene regulation by miRNAs.
  • Synthesis of current knowledge on miRNA roles as fine-tuners and safeguards.

Main Results:

  • MicroRNAs (miRNAs) are small non-coding RNAs with significant impact on cardiovascular development and disease.
  • miRNAs regulate gene expression post-transcriptionally, acting as fine-tuners and safeguards.
  • Dysregulation of miRNAs is implicated in cardiovascular abnormalities.

Conclusions:

  • miRNAs play critical roles in maintaining cardiovascular system homeostasis.
  • Understanding miRNA mechanisms provides insights into preventing and treating heart defects.
  • miRNAs represent a promising area for novel cardiovascular therapeutics.