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Association of hyperuricemia with renal outcomes, cardiovascular disease, and mortality

Wan-Chun Liu1, Chi-Chih Hung, Szu-Chia Chen

  • 1Department of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Taiwan.

Clinical Journal of the American Society of Nephrology : CJASN
|February 4, 2012
PubMed

Insights

Hyperuricemia is linked to increased mortality and cardiovascular events in chronic kidney disease (CKD) patients. However, it does not appear to be a significant risk factor for renal replacement therapy or disease progression in this population.

Area of Science:

  • Nephrology
  • Cardiology
  • Public Health

Background:

  • Hyperuricemia is a known risk factor for mortality and cardiovascular and renal diseases.
  • Its association with clinical outcomes in chronic kidney disease (CKD) patients remains debated.

Purpose of the Study:

  • To investigate the relationship between uric acid levels and clinical outcomes in patients with stages 3-5 CKD.
  • To assess the association with all-cause mortality, cardiovascular events, renal replacement therapy, and rapid renal progression.

Main Methods:

  • A cohort of 3303 patients with stages 3-5 CKD was studied.
  • The association between uric acid levels and adverse outcomes was analyzed over a median follow-up of 2.8 years.

Main Results:

  • Hyperuricemia was associated with increased risks of all-cause mortality (aHR 1.85) and cardiovascular events (aHR 1.42).
  • No significant association was found between hyperuricemia and the risk of renal replacement therapy (aHR 0.96) or rapid renal progression (aHR 1.30).

Conclusions:

  • In patients with stages 3-5 CKD, hyperuricemia is a significant risk factor for all-cause mortality and cardiovascular events.
  • Hyperuricemia is not a significant risk factor for renal replacement therapy or rapid renal progression in this patient group.
Abstract

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