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Consensus-based standards for best supportive care in clinical trials in advanced cancer.

S Yousuf Zafar1, David C Currow, Nathan Cherny

  • 1Division of Medical Oncology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA. yousuf.zafar@duke.edu

The Lancet. Oncology
|February 4, 2012

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View abstract on PubMed

Summary

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  • Biomedical And Clinical Sciences
  • Oncology And Carcinogenesis
  • Predictive And Prognostic Markers
  • Consensus-based Standards For Best Supportive Care In Clinical Trials In Advanced Cancer.
    • This summary is machine-generated.

    Developing standardized best supportive care (BSC) in clinical trials is crucial. Experts reached consensus on 11 statements across four domains to improve BSC delivery and study replication.

    Area of Science:

    • Oncology
    • Clinical Trials
    • Evidence-Based Practice

    Background:

    • Best supportive care (BSC) lacks standardized definition and delivery in clinical trials.
    • A consistent framework is needed for reproducible and evidence-based BSC.

    Purpose of the Study:

    • To develop consensus-based standards for best supportive care in clinical trials.
    • To establish a framework for consistent BSC delivery and study replication.

    Main Methods:

    • A panel of 36 experts utilized the Delphi method to achieve consensus.
    • Consensus was defined as >70% of panelists agreeing on a 5-point Likert scale.
    • Iterative rounds of questions and scoring were employed.

    Main Results:

    • Consensus was reached on 11 statements across four key domains: multidisciplinary care, supportive care documentation, symptom assessment, and symptom management.
    • A strong agreement (96%) was achieved for identical symptom assessment intervals between control and experimental groups.
    • Resource availability was identified as a significant challenge to implementing BSC standards.

    Conclusions:

    • The study established 11 consensus statements for best supportive care in clinical trials.
    • These standards aim to enhance the quality, consistency, and replicability of BSC.
    • Implementation challenges, such as resource limitations, require further attention.

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