Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Radical Autoxidation01:20

Radical Autoxidation

The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...
Cellular Injury I: Introduction01:00

Cellular Injury I: Introduction

Cellular injury occurs when a cell cannot maintain homeostasis or adapt to stressors such as hypoxia, toxins, or trauma. Depending on severity and duration, injury may be reversible, allowing recovery, or irreversible, leading to cell death.General Mechanisms of Cell InjuryAlthough causes vary, most cellular injuries arise from a few key mechanisms that disrupt essential functions and often amplify one another. Cell survival depends on the extent and balance of these disturbances.ATP depletion...
Oxygen Requirements and Growth Patterns01:29

Oxygen Requirements and Growth Patterns

Microorganisms exhibit diverse oxygen requirements and growth patterns driven by their metabolic strategies and environmental adaptations. Oxygen, while essential for many organisms, can also be toxic under certain conditions, shaping how microorganisms grow and survive.Oxygen Requirements of MicroorganismsMicroorganisms are classified based on their ability to use or tolerate oxygen:â—Ź Obligate aerobes like Mycobacterium tuberculosis need oxygen for energy production, as it serves as the...
Electron Transport Chain: Complex III and IV01:43

Electron Transport Chain: Complex III and IV

During the electron transport chain, electrons from NADH and FADH2 are first transferred to complexes I and II, respectively. These two complexes then transfer the electrons to ubiquinol, which carries them further to complex III. Complex III passes the electrons across the intermembrane space to Cyt c, which carries them further to complex IV. Complex IV donates electrons to oxygen and reduces it to water. As electrons pass through complexes I, III, and IV, the energy released aids the pumping...
Peroxisomes01:24

Peroxisomes

Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...
Peroxisomes01:24

Peroxisomes

Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparison of Intensive Versus Conventional Glycemic Control Targets: An Updated Systematic Review and Meta-Analysis of the 2024 Society of Critical Care Medicine Guidelines on Glycemic Control for Critically Ill Adults.

Critical care medicine·2026
Same author

Authors reply: "Evolution of triglyceride and total cholesterol levels after critical illness: Preliminary insights into post-ICU metabolic sequelae".

Journal of critical care·2026
Same author

Feeding the injured brain: nutrients, dose, timing, and monitoring.

Intensive care medicine·2026
Same author

Nutrition interventions and post-intensive care syndrome: A narrative review.

Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition·2026
Same author

Evolution of triglyceride and total cholesterol levels after critical illness: Preliminary insights into post-ICU metabolic sequelae.

Journal of critical care·2026
Same author

Exploration of Predictive Factors for Acute Radiotherapy-Induced Gastro-Intestinal Symptoms in Prostate Cancer Patients.

Cancers·2025
Same journal

Postoperative body mass index and the risk of unfavorable outcomes in adults following esophagectomy for esophageal cancer: A retrospective cohort study.

JPEN. Journal of parenteral and enteral nutrition·2026
Same journal

Characterization of patients with medically unexplained intolerance to enteral feeding treated with home parenteral nutrition: A descriptive cohort study.

JPEN. Journal of parenteral and enteral nutrition·2026
Same journal

Association between blood phosphorus level and clinical outcomes in critically ill patients: A systematic review and meta-analysis.

JPEN. Journal of parenteral and enteral nutrition·2026
Same journal

Decreased bone mineral density in adults with type 2 intestinal failure: A descriptive cross-sectional study.

JPEN. Journal of parenteral and enteral nutrition·2026
Same journal

JPEN Journal Club 102. The Hochberg Procedure.

JPEN. Journal of parenteral and enteral nutrition·2026
Same journal

Longitudinal changes of skeletal muscle mass and architecture in critically ill adults: A prospective matched cohort study.

JPEN. Journal of parenteral and enteral nutrition·2026
See all related articles

Related Experiment Video

Updated: May 25, 2026

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors
09:33

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors

Published on: February 7, 2018

Oxidative stress.

Jean-Charles Preiser1

  • 1Department of Intensive Care, Erasme University Hospital, Brussels, Belgium. Jean-Charles.Preiser@erasme.ulb.ac.be

JPEN. Journal of Parenteral and Enteral Nutrition
|February 4, 2012
PubMed
Summary
This summary is machine-generated.

Oxidative stress, an imbalance in reactive oxygen species (ROS) and antioxidants, damages cells but is vital for mitochondrial energy production. Its role in aging, disease, and exercise requires rigorous scientific evaluation for effective medical applications.

More Related Videos

Analyzing Oxidative Stress in Murine Intestinal Organoids using Reactive Oxygen Species-Sensitive Fluorogenic Probe
09:31

Analyzing Oxidative Stress in Murine Intestinal Organoids using Reactive Oxygen Species-Sensitive Fluorogenic Probe

Published on: September 17, 2021

Analysis of Oxidative Stress in Zebrafish Embryos
11:05

Analysis of Oxidative Stress in Zebrafish Embryos

Published on: July 7, 2014

Related Experiment Videos

Last Updated: May 25, 2026

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors
09:33

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors

Published on: February 7, 2018

Analyzing Oxidative Stress in Murine Intestinal Organoids using Reactive Oxygen Species-Sensitive Fluorogenic Probe
09:31

Analyzing Oxidative Stress in Murine Intestinal Organoids using Reactive Oxygen Species-Sensitive Fluorogenic Probe

Published on: September 17, 2021

Analysis of Oxidative Stress in Zebrafish Embryos
11:05

Analysis of Oxidative Stress in Zebrafish Embryos

Published on: July 7, 2014

Area of Science:

  • Biochemistry
  • Cell Biology
  • Pathophysiology

Background:

  • Oxidative stress arises from an imbalance between reactive oxygen species (ROS) and antioxidant defenses.
  • While excessive ROS cause cellular damage and tissue destruction, ROS are essential for cellular functions like mitochondrial energy production.
  • Elevated oxidative stress is implicated in aging, exercise physiology, and various pathologies including cancer, neurodegenerative diseases, cardiovascular diseases, diabetes, and inflammatory conditions.

Purpose of the Study:

  • To evaluate the complex role of oxidative stress in physiological and pathological conditions.
  • To assess the efficacy of antioxidant interventions.
  • To determine the appropriate role of modulating oxidative pathways in human medicine.

Main Methods:

  • Review of existing literature on oxidative stress.
  • Analysis of the dual role of ROS in cellular function and damage.
  • Examination of clinical outcomes related to antioxidant therapies.

Main Results:

  • Oxidative stress contributes to cellular damage and is linked to numerous diseases and aging.
  • Reactive oxygen species (ROS) play a necessary role in cellular energy metabolism.
  • Antioxidant-based prevention strategies have shown limited success.

Conclusions:

  • A precise understanding of oxidative stress mechanisms is crucial.
  • Rigorous scientific evaluation under controlled conditions is necessary.
  • The therapeutic potential of targeting oxidative pathways requires further investigation for clinical application.