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Intrauterine Drug Delivery Systems

Intrauterine Drug Delivery Systems

Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...

Modified-Release Drug Delivery Systems: Rate-Programmed II

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...

Drug Delivery Systems: Different Types

Drug Delivery Systems: Different Types

Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...

Modified-Release Drug Delivery Systems: Rate-Programmed I

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...

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Related Experiment Video

Updated: May 25, 2026

A New Ex Vivo Model for the Evaluation of Endoscopic Submucosal Injection Material Performance

A New Ex Vivo Model for the Evaluation of Endoscopic Submucosal Injection Material Performance

Published on: October 19, 2018

Injectable drug-eluting elastomeric polymer: a novel submucosal injection material.

Richard T Tran¹, Michael Palmer, Shou-Jiang Tang

¹Department of Bioengineering, The University of Texas at Arlington, 500 UTA Boulevard, Arlington, TX 76010-0138, USA.

Gastrointestinal Endoscopy

|February 4, 2012

Summary

An injectable drug-eluting elastomeric polymer (iDEEP) shows promise as a submucosal injection material for endoscopic resection. It provides superior submucosal elevation and controlled drug release, potentially improving efficacy in EMR and ESD procedures.

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Last Updated: May 25, 2026

A New Ex Vivo Model for the Evaluation of Endoscopic Submucosal Injection Material Performance

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Published on: October 19, 2018

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An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

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Published on: June 7, 2015

Area of Science:

Gastroenterology
Biomaterials Science
Endoscopic Surgery

Background:

Biodegradable hydrogels are crucial for delivering therapeutic payloads in Endoscopic Mucosal Resection (EMR) and Endoscopic Submucosal Dissection (ESD).
These materials aim to enhance treatment efficacy and promote mucosal regeneration.
Current injection materials require optimization for improved submucosal lifting and drug delivery.

Purpose of the Study:

To evaluate the efficacy of an injectable drug-eluting elastomeric polymer (iDEEP) as a novel submucosal injection material.
To compare iDEEP with existing materials like saline and sodium hyaluronate.
To assess iDEEP's performance in terms of injection pressure, drug release, submucosal elevation, and efficacy in endoscopic procedures.

Main Methods:

A comparative study involving material characterization tests.
Ex vivo and in vivo porcine models were utilized to simulate endoscopic submucosal dissection conditions.
Three solutions (saline, sodium hyaluronate, and iDEEP) were tested for submucosal cushion creation.

Main Results:

iDEEP demonstrated comparable injection pressures to sodium hyaluronate.
In vitro studies showed a controlled release of rebamipide from iDEEP for up to two weeks.
iDEEP achieved significantly greater submucosal elevation heights compared to saline and sodium hyaluronate, facilitating successful EMR procedures.

Conclusions:

iDEEP shows potential as an advanced injection material for endoscopic resection.
The study suggests iDEEP could be a significant advancement for EMR and ESD procedures.
Further research may validate iDEEP as an ideal material for endoscopic submucosal injection.