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Related Concept Videos

Sutures of the Skull01:22

Sutures of the Skull

The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these bones meet are called sutures.
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...
Cranial Bones: Superior and Posterior View01:14

Cranial Bones: Superior and Posterior View

The superior view of the cranium shows the frontal and paired parietal bones.
The frontal bone is the single bone that forms the forehead. At its anterior midline, between the eyebrows, there is a slight depression called the glabella. The frontal bone also forms the supraorbital margin of the orbit. Near the middle of this margin is the supraorbital foramen, the opening that provides passage for a sensory nerve to the forehead. The frontal bone is thickened just above each supraorbital margin,...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
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The Retinoblastoma Gene01:20

The Retinoblastoma Gene

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Overview of the Skull01:08

Overview of the Skull

The cranium (skull) is the skeletal structure of the head that supports the face and protects the brain. It is subdivided into the facial bones and the brain case, or cranial vault. The facial bones underlie the facial structures, form the nasal cavity, enclose the eyeballs, and support the teeth of the upper and lower jaws.
The cranial vault surrounds and protects the brain and houses the middle and inner ear structures. This cavity is bounded superiorly by the rounded top of the skull, which...

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Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device
07:44

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device

Published on: May 2, 2025

Primary pediatric skull tumors.

Melanie G Hayden Gephart1, Elizabeth Colglazier, Kayla L Paulk

  • 1Department of Neurosurgery, Stanford University Medical Center, Stanford, CA 94305, USA.

Pediatric Neurosurgery
|February 4, 2012
PubMed
Summary
This summary is machine-generated.

Pediatric skull tumors are often dermoid cysts or fibrous dysplasia. Location, age, and size help diagnose these tumors, with CT scans often sufficient for presurgical evaluation.

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Area of Science:

  • Pediatric Neurosurgery
  • Oncology
  • Radiology

Background:

  • Primary skull tumors in children are rare but require accurate diagnosis.
  • Understanding the pathological distribution is crucial for effective management.

Purpose of the Study:

  • To review the pathological distribution of pediatric primary skull tumors.
  • To determine the diagnostic value of lesion location, patient age, and lesion size.

Main Methods:

  • Retrospective chart review of 51 pediatric patients with 54 primary skull tumors.
  • Data collected from 2005 to 2010.

Main Results:

  • Dermoid cysts (n=34) and fibrous dysplasia (n=5) were the most common diagnoses.
  • Midline lesions suggested dermoid cysts (PPV=0.88), while lateral lesions indicated fibrous dysplasia (NPV=1).
  • Age (< or >5 years) and size (≤2 cm for dermoid cysts, >2 cm for fibrous dysplasia) provided significant diagnostic clues.

Conclusions:

  • Dermoid cysts and fibrous dysplasia are the most frequent pediatric primary skull tumors.
  • Lesion location, patient age, and size are valuable diagnostic indicators.
  • Clinical diagnosis based on CT is often adequate for presurgical planning.