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Updated: May 25, 2026

A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis
Published on: May 22, 2018
Interference of a new cyclometallated Pt compound with Cu binding to amyloid-β peptide
Isabelle Sasaki1, Christian Bijani, Sonia Ladeira
1CNRS, LCC (Laboratoire de Chimie de Coordination), Toulouse, France. isabelle.sasaki@lcc-toulouse.fr
Abstract:
Coordination of a cyclometallated Pt(II) complex (1) to an amyloid-β peptide was probed by NMR and ESI-MS. Furthermore, EPR showed that binding of 1 to the Cu(II)-amyloid-β species resulted in a reshuffling of the Cu(II) coordination sphere, which was absent or lower for the sister non cyclometallated Pt(II) complexes.
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