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Up-to-date management of gout
1Rheumatology Department, Royal Sussex County Hospital, Brighton and Sussex University Hospitals NHS Trust, Eastern Road, Brighton, BN2 5BE, UK. Kelsey.Jordan@bsuh.nhs.uk
Current Opinion in Rheumatology
|February 4, 2012
Summary
Gout is a curable crystal disease often undertreated. This review covers modern and established treatments, emphasizing a treat-to-target approach for effective gout management and cure.
Area of Science:
- Rheumatology
- Crystal Arthropathies
- Pharmacology
Background:
- Gout is a crystal deposition disease causing significant pain and joint damage.
- Despite being curable, gout is frequently undertreated and mismanaged.
- Misconceptions about gout link it to patient lifestyle, hindering proper care.
Purpose of the Study:
- To provide a comprehensive understanding of gout management.
- To review established and novel pharmacological and non-pharmacological treatments for acute and chronic gout.
- To introduce the concept of 'treat to target' for gout cure.
Main Methods:
- Review of modern and established pharmacological treatments.
- Inclusion of non-pharmacological management strategies.
- Focus on achieving urate targets for disease resolution.
Main Results:
- Gout management relies on treatments developed since the 1970s-1980s.
- Recent advancements include anti-IL inhibitors, non-xanthine oxidase inhibitors, and uricase enzymes.
- Improved physiological understanding drives new therapeutic options.
Conclusions:
- Established gout treatments can be optimized through new research.
- Effective management involves treating patients to a specific urate target.
- Raising the profile of gout is crucial for its best management and cure.
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