Related Experiment Video

Updated: May 25, 2026

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation
06:39

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation

Published on: August 19, 2020

An explorative analysis of secretory receptor for advanced glycation endproducts in primary focal segmental

Harin Rhee1, Sang Heon Song, Ihm Soo Kwak

  • 1Division of Nephrology, Department of Internal Medicine, Pusan National University School of Medicine, 179 Gudeok-ro, Seo-gu, Busan 602-739, Republic of Korea.

Clinical and Experimental Nephrology
|February 4, 2012
PubMed
Abstract

Insights

Endogenous secretory receptor for advanced glycation endproducts (esRAGE) levels were higher in focal segmental glomerulosclerosis (FSGS) patients compared to IgA nephropathy and controls. Higher esRAGE correlated with increased proteinuria in FSGS.

Area of Science:

  • Nephrology
  • Immunology
  • Endocrinology

Background:

  • Focal segmental glomerulosclerosis (FSGS) pathogenesis remains unclear, with poor prognosis.
  • Receptor for advanced glycation endproducts (RAGE) is implicated in diabetic nephropathy but its role in glomerulonephritis is unexplored.
  • Investigating RAGE in primary FSGS is crucial for understanding disease mechanisms.

Purpose of the Study:

  • To explore the relationship between clinical parameters and soluble RAGE (sRAGE) in primary FSGS.
  • To compare serum levels of sRAGE and its variants in primary FSGS, IgA nephropathy (IgAN), and healthy controls.

Main Methods:

  • Serum levels of carboxymethyl-lysin (CML), sRAGE, and endogenous secretory RAGE (esRAGE) were measured.
  • A cohort of 35 subjects was divided into primary FSGS (N=15), IgAN (N=10), and control (N=10) groups.
  • Statistical analyses, including correlation and regression, were performed to assess relationships.

Main Results:

  • Serum esRAGE levels were significantly higher in the FSGS group compared to the IgAN and control groups (p=0.013).
  • No significant differences in sRAGE or CML levels were observed among the groups.
  • Within the FSGS group, esRAGE positively correlated with 24-hour urinary protein (r=0.553, p=0.033) and negatively with BMI (r=-0.623, p=0.013).

Conclusions:

  • Serum esRAGE, but not sRAGE, is elevated in primary FSGS patients.
  • 24-hour proteinuria is a significant clinical parameter associated with serum esRAGE levels in FSGS.
  • These findings suggest a potential role for esRAGE in FSGS pathophysiology.

More Related Videos

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Proteoglycans01:05

Proteoglycans

Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...