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Related Experiment Video

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Grey matter volume alterations in CADASIL: a voxel-based morphometry study.

Maria Camilla Rossi Espagnet1, Andrea Romano2, Filippo Carducci3

  • 1Neurosciences and Sensory Organs Department, Neuroradiology, Faculty of Medicine and Psychology, Sant'Andrea Hospital, University Sapienza, Via di Grottarossa 1035, 00139 Rome, Italy. camilla.rossiespagnet@gmail.com.

The Journal of Headache and Pain
|February 4, 2012
PubMed
Summary

Cerebral autosomal dominant arteriopathy with subcorticalначала microangiopathy (CADASIL) patients show reduced grey matter volume in temporal lobes, linked to overall white matter lesions. This suggests complex brain damage interactions in this hereditary condition.

Keywords:
CADASILDARTELDementiaVBM

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Area of Science:

  • Neuroimaging
  • Neurology
  • Genetics

Background:

  • Cerebral autosomal dominant arteriopathy with subcortical microangiopathy (CADASIL) is a hereditary cerebrovascular disease.
  • It causes early strokes and cognitive decline due to cerebral subcortical microangiopathy.
  • Grey matter (GM) involvement in CADASIL is not fully understood.

Purpose of the Study:

  • To evaluate grey matter (GM) volume alterations in CADASIL patients compared to healthy controls.
  • To investigate correlations between white matter (WM) lesion load and GM volume changes.

Main Methods:

  • 14 CADASIL patients and 12 healthy controls underwent 1.5 T brain MRI.
  • Optimized-voxel based morphometry (VBM) was used for volumetric analysis.
  • Regression analyses explored correlations between WM lesion load and GM atrophy.

Main Results:

  • CADASIL patients exhibited significant GM volume reductions in bilateral temporal lobes compared to controls (p < 0.05, FDR-corrected).
  • A correlation was found between total WM lesion load and temporal GM atrophy in patients (p < 0.05, uncorrected).
  • No correlation was observed between temporal WM lesion load and temporal GM atrophy.

Conclusions:

  • CADASIL is associated with temporal lobe GM atrophy.
  • This atrophy relates to the overall white matter (WM) lesion burden, not specifically temporal WM lesions.
  • Complex interactions between subcortical and cortical damage are hypothesized in CADASIL pathogenesis.