Related Experiment Videos
Managing Perianal Crohn’s Disease.
Dawn M Wiese1, David A Schwartz
1Vanderbilt University Medical Center, Nashville, TN 37232-5283, USA. dawn.m.wiese@vanderbilt.edu
Current Gastroenterology Reports
|February 4, 2012
Summary
Perianal Crohn's Disease (CD) requires advanced imaging for accurate diagnosis. Anti-TNF agents, antibiotics, and immunomodulators are key treatments, improving outcomes for this challenging condition.
Area of Science:
- Gastroenterology
- Inflammatory Bowel Disease Research
- Surgical Gastroenterology
Background:
- Perianal Crohn's Disease (CD) significantly impacts patient morbidity.
- Accurate diagnosis relies on advanced imaging alongside physical examination.
- Treatment aims to manage both perianal and intestinal symptoms.
Purpose of the Study:
- To review current diagnostic and therapeutic strategies for perianal Crohn's Disease.
- To highlight the role of advanced imaging in identifying perianal involvement.
- To discuss the efficacy of established and emerging treatment modalities.
Main Methods:
- Literature review of diagnostic imaging techniques for perianal CD.
- Analysis of current medical and surgical treatment protocols.
- Evaluation of the impact of anti-TNF agents and other therapies.
Main Results:
- Advanced imaging is crucial for precise identification of perianal disease.
- Anti-TNF agents represent a cornerstone in managing perianal CD, alongside antibiotics and immunomodulators.
- Treatment strategies are tailored to disease severity for optimal patient response.
Conclusions:
- Effective management of perianal Crohn's Disease necessitates a comprehensive approach.
- Current therapies, particularly anti-TNF agents, have significantly improved treatment outcomes.
- Further research is needed to support the use of novel experimental therapies.
Related Concept Videos
01:21Inflammatory Bowel Disease V: Surgical Management
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
01:29Inflammatory Bowel Disease IV: Pharmacological Management
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...
01:30Inflammatory Bowel Disease II: Crohn's Disease
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2 (COX-2),...