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Updated: May 25, 2026

Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats
Published on: March 28, 2025
Non-immune hydrops fetalis: a short review of etiology and pathophysiology
Carlo Bellini1, Raoul C M Hennekam
1Neonatal Intensive Care Unit, Department of Paediatrics, Gaslini Institute, University of Genoa, Genova, Italy. carlobellini@ospedale-gaslini.ge.it
Abstract:
Hydrops fetalis is an excessive accumulation of fetal fluid. Hydrops is traditionally classified into either immune or non-immune hydrops (NIHF), but in practice, nowadays in the Western world >90% of hydrops is of non-immune origin. The basis of the disorder is an imbalance in the regulation of fetal fluid movement between the vascular and interstitial space. We previously suggested a diagnostic flow-chart for NIHF. In this short review we describe the main mechanisms leading to NIHF.
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