Related Experiment Videos
Arterial stenting with self-expandable and balloon-expandable endoprostheses
W J van der Giessen1, P W Serruys, L J van Woerkens
1Department of Cardiology, Thoraxcenter, The Netherlands.
International Journal of Cardiac Imaging
|January 1, 1990
Summary
Vascular stents can reduce complications from angioplasty. Self-expandable stents (SES) showed 100% patency with antithrombotic treatment, while balloon-expandable stents (BES) achieved 100% patency without it in swine models.
Area of Science:
- Cardiovascular research
- Biomedical engineering
- Interventional cardiology
Background:
- Coronary angioplasty complications include acute occlusion (2-5%) and late restenosis (20-40%).
- Vascular endoprostheses (stents) offer a potential solution to these complications.
- Metallic stents are undergoing evaluation for clinical use.
Purpose of the Study:
- To evaluate the performance of two metallic stents in swine arteries.
- To compare self-expandable stents (SES) and balloon-expandable stents (BES) in normal arteries.
- To assess the impact of antithrombotic therapy on stent patency.
Main Methods:
- Implantation of self-expandable stainless steel stents (3.5 mm) in peripheral swine arteries (n=17), some deendothelialized.
- Implantation of SES (3.0 and 3.5 mm) and tantalum balloon-expandable stents (BES) in normal coronary arteries of swine.
- Post-implantation antithrombotic therapy varied: acenocoumarol and aspirin, aspirin alone, coumadines, or no treatment.
Main Results:
- All peripheral stented arteries were patent after 1 week with complete neointimal coverage.
- Untreated SES in coronary arteries showed a 38% occlusion rate within 48 hours, with 62% patency at 1 week.
- SES treated with coumadines and untreated BES demonstrated 100% patency at 1 week in coronary arteries.
Conclusions:
- Self-expandable stents (SES) require antithrombotic treatment (coumadines) to achieve 100% patency in normal swine coronary arteries.
- Balloon-expandable stents (BES) demonstrated 100% patency without antithrombotic treatment in normal swine coronary arteries.
- Stent design and antithrombotic regimen significantly influence patency rates.