Systemic idazoxan impairs performance in a non-reversal shift test: implications for the role of the central...

Two experiments examined the effect of pharmacological stimulation of the locus coeruleus in a non-reversal shift paradigm to test predictions concerning the role of the ceruleo-cortical noradrenergic system in processes of selective attention. Food-deprived rats were trained to make either visual (experiment 1) or spatial (experiment 2) discriminations in a parallel alley with both sets of cues being present at all times. Two groups of rats received treatments of either 2 mg/kg i.p. of the selective α(2) adrenoceptor antagonist idazoxan or saline control injections before each daily block of trials. Following attainment of criterion, the reinforcement contingencies were altered according to a non-reversal shift design, so that the alternative (i.e. either spatial or visual) set of cues now predicted reward. Rats treated with idazoxan were not impaired in the acquisition of either the spatial or visual discrimination task, but they were impaired in both forms of non-reversal shift. These deficits are interpreted as resulting from narrowed attention in idazoxan-treated rats, thus supporting a selective attention hypothesis of locus coeruleus function.