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Related Concept Videos

RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...

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Related Experiment Video

Updated: May 25, 2026

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
10:06

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

Trans-splicing in Higher Eukaryotes: Implications for Cancer Development?

Peter G Zaphiropoulos1

  • 1Department of Biosciences and Nutrition, Karolinska Institutet Huddinge, Sweden.

Frontiers in Genetics
|February 4, 2012
PubMed
Summary
This summary is machine-generated.

Trans-splicing, where exons from different pre-mRNAs join, is gaining recognition. Recent studies suggest trans-spliced molecules may guide chromosomal rearrangements in human tumors.

Keywords:
RNAevolutionexongenerecombination

More Related Videos

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
11:48

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition

Published on: October 9, 2014

Related Experiment Videos

Last Updated: May 25, 2026

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
10:06

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
11:48

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition

Published on: October 9, 2014

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • Trans-splicing, the joining of exons from separate pre-messenger RNA molecules, has historically been considered a minor gene expression mechanism.
  • Recent research indicates a potential role for trans-splicing in the development of human cancers.
  • This process involves the formation of chimeric RNA molecules.

Purpose of the Study:

  • To review the evolving understanding of trans-splicing in higher eukaryotes over the past 25 years.
  • To highlight the growing evidence supporting trans-splicing as a significant biological event.
  • To explore the proposed role of trans-splicing in genomic rearrangements associated with cancer.

Main Methods:

  • Literature review and synthesis of recent scientific findings.
  • Analysis of studies investigating gene expression mechanisms in eukaryotes.
  • Examination of research linking trans-splicing to chromosomal abnormalities.

Main Results:

  • Trans-splicing is transitioning from a poorly understood phenomenon to a recognized biological process.
  • Evidence suggests trans-splicing events may precede chromosomal rearrangements in human tumors.
  • Trans-spliced molecules are hypothesized to facilitate genomic translocations.

Conclusions:

  • The significance of trans-splicing in gene expression is increasingly acknowledged.
  • Trans-splicing may play a crucial role in the pathogenesis of certain cancers.
  • Further research is warranted to fully elucidate the mechanisms and implications of trans-splicing.