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00:46What is the Endocrine System?
The endocrine system sends hormones—chemical signals—through the bloodstream to target cells—the cells the hormones selectively affect. These signals are produced in endocrine cells, secreted into the extracellular fluid, and then diffuse into the blood. Eventually, they diffuse out of the blood and bind to target cells which have specialized receptors to recognize the hormones.
01:29The Endocrine System
The endocrine system is an extensive network of glands – organs or tissues in the body that create chemicals that control many bodily functions, that secrete hormones, which are chemical messengers that play essential roles in regulating various bodily functions. These hormones are secreted into the bloodstream and travel throughout the body. They require specific receptors to convey signals to cells possessing these corresponding receptors. This complex signaling mechanism ensures that every...
00:59Structures of the Endocrine System
The intricate framework of the endocrine system encompasses a diverse array of glands, with their target tissues and organs strategically distributed throughout the body. Central to this network are the endocrine glands, specialized structures that lack ducts and release hormones directly into the interstitial fluid. Notably, the hypothalamus, a vital neuroendocrine organ situated in the brain, governs neural functions and serves as a potent source of hormonal regulation. Near the hypothalamus...
01:10An Overview of the Endocrine System
The endocrine system, a complex network of glands, orchestrates physiological balance within the body through the production and secretion of hormones. These hormones are chemical messengers in intercellular communication, acting as conduits between the secretory cells and distant target sites. They traverse the circulatory system by being released into the extracellular fluid, and their impact is specific to cells possessing receptors for a particular hormone.
The endocrine system collaborates...
The endocrine system collaborates...
01:33Hormonal Regulation
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
01:40Hormonal Regulation
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
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Related Experiment Video
Updated: May 25, 2026
09:29
Isolation of Targeted Hypothalamic Neurons for Studies of Hormonal, Metabolic, and Electrical Regulation
Published on: August 4, 2023
[Endocrinology].
1Service de médecine interne générale, HUG, 1211 Genève 14. adriana.missana@hcuge.ch
Revue Medicale Suisse
|February 7, 2012
Summary
New molecular biology findings offer novel endocrine tumor treatments. Pasireotide shows promise for Cushing's disease by targeting pituitary adenomas, while tyrosine-kinase inhibitors yield encouraging results for thyroid cancers.
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Area of Science:
- Endocrinology
- Molecular Biology
- Oncology
Background:
- Cushing's disease lacks targeted pituitary adenoma therapies.
- Thyroid cancer progression involves kinase signaling.
- Limited treatment options exist for advanced differentiated thyroid carcinomas and medullary carcinomas.
Purpose of the Study:
- To explore new therapeutic strategies for endocrine tumors based on recent molecular biology discoveries.
- To evaluate the potential of pasireotide in treating Cushing's disease.
- To assess the efficacy of tyrosine-kinase inhibitors in advanced thyroid cancers.
Main Methods:
- Review of recent clinical trials and molecular biology findings.
- Assessment of pasireotide's affinity for somatostatin receptors on corticotroph adenomas.
- Analysis of tyrosine-kinase inhibitors' effects on progressive differentiated iodine-refractory thyroid carcinomas and medullary carcinomas.
Main Results:
- Pasireotide, a somatostatin analog, targets somatostatin receptors on pituitary adenomas relevant to Cushing's disease.
- Clinical trials indicate pasireotide can decrease urinary free cortisol levels.
- Tyrosine-kinase inhibitors have shown modestly encouraging results in treating advanced thyroid carcinomas.
Conclusions:
- Pasireotide represents a potential medical therapy for Cushing's disease, particularly after surgical failure.
- Tyrosine-kinase inhibitors offer a new avenue for managing progressive differentiated and medullary thyroid cancers.
- Advances in molecular biology are driving innovative treatments for endocrine malignancies.