Automated supported liquid extraction using 2D barcode processing for routine toxicokinetic portfolio support
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Joseph A Tweed1, Justin Walton, Zhenhua Gu
1Pharmacokinetics, Dynamics & Metabolis, Pfizer Global Research & Development, Pfizer Inc., MS8118D-2047, Groton, CT 06340, USA. joseph.tweed@pfizer.com
Background:
A new bioanalytical sample preparation approach has been developed to enhance the efficiency, reduce errors and improve the data quality supporting routine toxicokinetic (TK) study samples analysis, via the implementation of 2D barcode processing coupled with fully automated supported liquid extraction (SLE).
Results:
A fully automated SLE was validated and used to determine TK drug concentrations of over 500 unknown samples via 2D barcode processing. Assay performance calculated from a total of 291 quality control samples over the period of validation through sample analysis demonstrated inter-day precision and accuracy within 10 and 7.3%, respectively.
Conclusion:
A new logistical approach implementing the use of 2D barcodes and automated SLE demonstrates the potential of a new methodology for the routine bioanalytical support of TK study sample analysis.
