Related Experiment Video
Updated: May 25, 2026

06:32
Reconstitution of Septin Assembly at Membranes to Study Biophysical Properties and Functions
Published on: July 28, 2022
Segregation by membrane rigidity in flowing binary suspensions of elastic capsules
1Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.
Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
|February 7, 2012
Summary
In binary mixtures of capsules with different rigidities flowing in a slit, stiff capsules move towards walls while floppy ones concentrate centrally. This segregation is driven by particle interactions and their proximity to walls.
Area of Science:
- Fluid Dynamics
- Soft Matter Physics
- Computational Mechanics
Background:
- Understanding particle behavior in complex fluids is crucial for various applications.
- Capsule suspensions exhibit unique flow dynamics due to their deformability.
- Spatial segregation in confined flows influences suspension properties.
Purpose of the Study:
- To investigate spatial segregation in binary mixtures of capsules with unequal rigidities.
- To analyze the influence of parameters like rigidity ratio and particle fraction on segregation.
- To elucidate the underlying mechanisms of particle migration and collision dynamics.
Main Methods:
- Numerical simulations using an accelerated boundary integral method.
- Investigation of pressure-driven flow of neo-Hookean capsules in a planar slit.
- Systematic variation of parameters: capillary number, rigidity ratio, volume fraction, confinement, and number fraction of floppy particles (Xf).
Main Results:
- In mixtures, stiff capsules increasingly migrate towards walls with higher Xf.
- Floppy capsules increasingly accumulate near the centerline as Xf decreases.
- Segregation is driven by altered near-wall localization and cross-stream migration during collisions.
Conclusions:
- The number fraction of floppy particles (Xf) dictates the degree of spatial segregation.
- Heterogeneous collisions significantly contribute to the observed cross-stream migration.
- A unified mechanism explains segregation through wall-induced migration and collision-driven fluxes.
Related Concept Videos
Size-Exclusion Chromatography
In size-exclusion chromatography (SEC), also known as molecular-exclusion or gel-permeation chromatography, molecules are separated based on their sizes. This technique is important for separating large molecules such as polymers and biomolecules. The two classes of micron-sized stationary phases encountered in SEC are silica particles and cross-linked polymer resin beads. Both materials are porous, but their pore sizes vary significantly.
Silica particles offer advantages such as rigidity,...
Silica particles offer advantages such as rigidity,...
The Colloidal State
The formation of a colloidal system is exemplified by an aqueous solution containing Cl− ions is introduced to another containing Ag+ ions, resulting in the precipitation of solid AgCl as extremely tiny crystals. Instead of settling out as a filterable precipitate, these crystals remain suspended in the liquid, showcasing a colloidal system.A colloidal system involves colloidal particles within the approximate range of 1 to 1000 nm in at least one dimension, dispersed in a medium called the...
Membrane Fluidity
Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.
Membrane Fluidity
Membrane fluidity is explained by the fluid mosaic model of the cell membrane, which describes the plasma membrane structure as a mosaic of components—including phospholipids, cholesterol, proteins, and carbohydrates—that gives the membrane a fluid character.
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is a relatively...
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is a relatively...
Mechanisms of Membrane-bending
The living membranes are flexible due to their fluid mosaic nature; however, their bending into different shapes is an active process regulated by specific lipids and proteins. The membrane bending can be transient as seen in vesicles or stable for a long time as in microvilli. Cells regulate the size, location, and duration of the membrane curvature.
Membrane bending can happen due to intrinsic changes in lipid composition or extrinsic association with different proteins. The proteins involved...
Membrane bending can happen due to intrinsic changes in lipid composition or extrinsic association with different proteins. The proteins involved...
Colloids and Suspensions
Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles visible to the naked eye or seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. The suspended particles in a suspension settle out after some time of mixing. The separation of particles from a suspension is...

