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Heart Failure Drugs: Diuretics

Heart Failure Drugs: Diuretics

Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...

Heart Failure VI: Adjunct Therapies

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.

Factors Affecting Renal Clearance: Renal Impairment

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
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Renal Failure: Dose Adjustments

Renal Failure: Dose Adjustments

In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
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Heart Failure II: Pathophysiology

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Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

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The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...

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Updated: May 25, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

[Renal function in patients with heart failure: prognostic value].

J Casado¹, M Montero, F Formiga

¹Servicio de Medicina Interna, Hospital del Henares, Coslada, Madrid, España. jmanuel.casado@salud.madrid.org

Revista Clinica Espanola

|February 7, 2012

Summary

This summary is machine-generated.

Nearly 60% of heart failure (HF) patients admitted to internal medicine have impaired renal function. This condition significantly increases the risk of all-cause mortality by twofold.

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Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

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Published on: June 10, 2025

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Last Updated: May 25, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Published on: June 10, 2025

Area of Science:

Nephrology
Cardiology
Internal Medicine

Context:

Heart failure (HF) is a significant health concern with impaired renal function often complicating patient prognosis.
The RICA study, a prospective multicenter cohort, enrolled patients admitted for decompensated HF across 52 Spanish Internal Medicine Departments.

Purpose:

To determine the prevalence of impaired renal function in hospitalized heart failure patients.
To evaluate the prognostic significance of renal dysfunction on mortality risk in this population.

Summary:

The study analyzed 714 patients (mean age 77.3 years, 54% women) admitted for decompensated heart failure.
59.5% of patients had an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m², with 11.2% having eGFR < 30 mL/min/1.73 m².
Impaired renal function was independently associated with a 2.05-fold increased risk of all-cause mortality (P=.018).

Impact:

Highlights the high prevalence of renal impairment in heart failure patients, a critical comorbidity.
Demonstrates that worsening renal function is a significant independent predictor of mortality in heart failure.
Suggests a potential need for closer monitoring and tailored treatment strategies for heart failure patients with renal dysfunction.