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Related Experiment Video

Updated: May 25, 2026

Protein Target Prediction and Validation of Small Molecule Compound

Protein Target Prediction and Validation of Small Molecule Compound

Published on: February 23, 2024

Finding a target for resveratrol.

Ruth I Tennen¹, Eriko Michishita-Kioi, Katrin F Chua

¹Department of Medicine, Division of Endocrinology, Gerontology, and Metabolism, Stanford University, Stanford, CA 94305, USA.

|February 7, 2012

Summary

Resveratrol

Area of Science:

Biochemistry and Molecular Biology
Metabolic Regulation

Background:

Resveratrol is known for its health benefits, but its precise molecular targets and mechanisms of action are not fully understood.
Identifying the direct molecular targets of resveratrol is crucial for understanding its physiological effects.

Discussion:

Park et al. demonstrate that resveratrol directly inhibits cyclic adenosine monophosphate (cAMP)-dependent phosphodiesterases.
This inhibition initiates a signaling pathway affecting key metabolic regulators.
The findings clarify a long-standing question regarding resveratrol's mechanism of action.

Key Insights:

Resveratrol directly targets and inhibits cAMP-dependent phosphodiesterases.
This action triggers a cascade influencing energy metabolism.

Related Experiment Videos

Last Updated: May 25, 2026

Protein Target Prediction and Validation of Small Molecule Compound

Protein Target Prediction and Validation of Small Molecule Compound

Published on: February 23, 2024

The study identifies a direct molecular interaction explaining resveratrol's effects on AMPK, SIRT1, and PGC-1α.

Outlook:

Further research can explore therapeutic strategies based on phosphodiesterase inhibition by resveratrol.
Understanding this pathway may lead to novel interventions for metabolic disorders.
This discovery provides a foundation for developing resveratrol-based or inspired drugs.