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In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
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Ovarian incidentaloma.

Meir Jonathon Solnik1, Carolyn Alexander

  • 1Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Geffen School of Medicine at UCLA, Los Angeles, CA 90048, USA. solnikm@cshs.org

Best Practice & Research. Clinical Endocrinology & Metabolism
|February 7, 2012
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Summary
This summary is machine-generated.

Most incidental ovarian cysts in post-menopausal women are benign and resolve on their own. Persistent or concerning cysts may require further imaging or surgical evaluation.

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Area of Science:

  • Gynecology
  • Radiology
  • Oncology

Background:

  • Incidental adnexal masses are common in post-menopausal women, affecting 3.3-18% of asymptomatic individuals.
  • Unilocular, benign-appearing ovarian cysts are the most frequent findings on transvaginal ultrasonography.

Purpose of the Study:

  • To review the management of incidental adnexal masses in post-menopausal women.
  • To differentiate between benign and malignant ovarian cysts.

Main Methods:

  • Review of existing literature on adnexal mass diagnosis and management.
  • Discussion of imaging modalities including transvaginal ultrasonography and MRI.
  • Analysis of clinical factors such as cyst characteristics, tumor markers (e.g., CA-125), and patient symptoms.

Main Results:

  • Approximately 80% of ovarian cysts resolve spontaneously within months.
  • Persistent, unchanged cysts <10 cm with normal CA-125 levels have a low risk of malignancy, supporting observation.
  • MRI can aid in distinguishing benign from malignant masses.

Conclusions:

  • Observation is a suitable approach for many persistent, asymptomatic adnexal cysts.
  • Surgical intervention is indicated for symptomatic patients, those with changing cyst characteristics, elevated tumor markers, or suspected hormone-producing neoplasms.
  • Evidence-based screening guidelines for adnexal masses are still under development.