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Sputum matrix metalloproteinase-12 in patients with chronic obstructive pulmonary disease and asthma: relationship to

Rekha Chaudhuri1, Charles McSharry, Jeffrey Brady

  • 1Respiratory Medicine, Institute of Infection, Immunity & Inflammation, University of Glasgow and Gartnavel General Hospital, Glasgow, G12 OYN Scotland, United Kingdom.

The Journal of Allergy and Clinical Immunology
|February 7, 2012
PubMed
Abstract

Insights

Matrix metalloproteinase (MMP)-12 levels in sputum correlate with COPD severity, particularly emphysema extent shown by CT scans. This suggests MMP-12 plays a role in COPD pathogenesis and could be a therapeutic target.

Area of Science:

  • Pulmonary Medicine
  • Biochemistry
  • Radiology

Background:

  • Matrix metalloproteinase (MMP)-12 is implicated in chronic obstructive pulmonary disease (COPD) and asthma pathogenesis.
  • The relationship between disease severity and sputum MMP-12 levels and activity is not well understood.

Purpose of the Study:

  • To investigate the association between disease severity (lung function and CT scans) and induced sputum MMP-12 concentrations and activity in asthma and COPD patients.

Main Methods:

  • 208 subjects (asthma, COPD, healthy controls) underwent sputum MMP-12 concentration (ELISA) and activity assays.
  • MMP12 mRNA expression, diffusing capacity for carbon monoxide (Dlco), and CT-assessed emphysema were measured.

Main Results:

  • Sputum MMP-12 concentrations were higher in COPD patients and asthmatic smokers compared to healthy non-smokers.
  • In COPD, CT-assessed emphysema severity directly correlated with sputum MMP-12 concentrations and activity.
  • No significant association was found between disease severity and sputum MMP-12 in asthma patients.

Conclusions:

  • Sputum MMP-12 concentrations and activity in COPD are linked to emphysema extent, supporting MMP-12's role in COPD pathogenesis.
  • Targeting MMP-12 activity may offer a strategy to prevent emphysema progression in COPD patients.

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