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Probiotics and otitis media in children
Leena Niittynen1, Anne Pitkäranta, Riitta Korpela
1Nutritionist Leena Niittynen, Kantotie 9, 03400 Vihti, Finland.
Insights
Probiotics show some promise in preventing and managing otitis media (OM) in children, with oral and nasal spray applications demonstrating potential benefits. However, more research is needed to confirm these findings and identify optimal strains.
Area of Science:
- Microbiology
- Pediatric Infectious Diseases
- Immunology
Background:
- Probiotics modulate gut microbiota and immune function, offering potential for infectious disease prophylaxis.
- Otitis media (OM) is a prevalent childhood bacterial infection, necessitating effective prevention and management strategies.
Purpose of the Study:
- To review current knowledge on the effects of probiotics in preventing and managing otitis media in children.
Main Methods:
- A comprehensive literature search was conducted on PubMed, including studies on probiotics and otitis media in children.
- Additional relevant publications were identified through the reference lists of selected articles.
Main Results:
- Limited studies exist, using diverse probiotic strains and populations.
- Oral probiotics showed reduced OM incidence in some healthy children and newborns but were ineffective in otitis-prone children.
- Nasal spray probiotics (alpha streptococci) improved clinical outcomes in recurrent or secretory OM in some studies.
Conclusions:
- Preliminary results for probiotics in otitis media are promising but inconclusive due to a lack of confirmatory studies.
- Further research is required to identify optimal probiotic strains and populations and elucidate their mechanisms of action in OM.
Objective:
An alternative option in the prophylaxis and the management of infectious diseases is the use of probiotics, which are known to stabilize gut microbiota and stimulate immune function. Otitis media (OM) is the most common bacterial infection in childhood. The aim of this review is to present the current knowledge of the effects of probiotics on OM.
Methods:
A PUBMED search was made to review the relevant literature, and publications on probiotics and otitis media in children were included. Additional studies were obtained from the references of the selected articles.
Results:
Only a few studies using different probiotic strains and study populations have investigated the effects of probiotics on OM. Five studies investigating the effects of oral probiotics, and three studies investigating the effect of probiotic nasal spray treatment were included in this review. Oral probiotics have reduced the incidence of OM in healthy children in one of two studies (days with OM: probiotic 0.5 vs. control 1.0; p=0.003) and in newborns in one of two studies (incidence of OM: probiotic 22%, placebo 50%; p=0.014), but has had no effect on OM in one study in otitis prone children. Nasal spray treatment containing α streptococci has led to clinical improvement in children with recurrent or secretory OM in two of three studies (cured: probiotic 42% vs. placebo 22%, p=0.02; recovery: probiotic 7/19 patients vs. placebo 1/17, p<0.05).
Conclusions:
Although there are some promising results, the lack of confirmative studies makes it difficult to draw any conclusions. More studies are needed to identify the most promising probiotic strains and study populations, and to evaluate the mechanisms behind the possible effects of probiotics on OM.
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