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Both El Tor and classical cholera toxin bind blood group determinants

Julie E Heggelund1, Espen Haugen, Birgitte Lygren

  • 1Department of Chemistry, University of Oslo, P.O. Box 1033, Blindern, NO-0315 Oslo, Norway.

Biochemical and Biophysical Research Communications
|February 7, 2012
PubMed
Summary

Cholera toxin B-pentamers bind to blood group determinants, explaining why blood group O individuals have severe cholera. Binding affinity is similar for blood group O and A, but kinetics differ.

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