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Updated: May 25, 2026
09:45
Production of Monoclonal Antibodies Targeting Aminopeptidase N in the Porcine Intestinal Mucosal Epithelium
Published on: May 18, 2021
Monoclonal antibodies for chronic refractory asthma and pipeline developments
Riccardo Polosa1, Thomas Casale
1Institute of Internal Medicine, G. Rodolico, Azienda Ospedaliero-Universitaria "Policlinico-Vittorio Emanuele", Università di Catania, Italy. polosa@unict.it
Drug Discovery Today
|February 7, 2012
Summary
Severe asthma patients need better treatments due to persistent symptoms and high healthcare costs. This review covers monoclonal antibodies, a promising new therapy targeting immune responses for improved asthma management.
Area of Science:
- Immunology
- Pulmonology
- Pharmacology
Background:
- Severe asthma significantly impacts patient quality of life and healthcare systems.
- Current high-intensity treatments are insufficient for many severe asthma patients.
- Understanding immune system pathways is crucial for developing advanced asthma therapies.
Purpose of the Study:
- To review the efficacy and safety of monoclonal antibodies for severe asthma.
- To discuss current and emerging monoclonal antibody therapies in clinical trials.
- To explore the role of these novel agents in specific severe asthma patient subgroups.
Main Methods:
- Systematic review of human clinical trial data.
- Analysis of efficacy and safety profiles of approved and investigational monoclonal antibodies.
- Discussion of future therapeutic targets and personalized medicine approaches.
Main Results:
- Monoclonal antibodies demonstrate significant efficacy in reducing exacerbations and improving symptoms in select severe asthma populations.
- Safety profiles vary among different monoclonal antibody agents, requiring careful patient selection.
- Ongoing research is identifying specific biomarkers for targeted therapy.
Conclusions:
- Monoclonal antibodies represent a significant advancement in treating severe asthma.
- Targeted therapies are essential for optimizing treatment outcomes in distinct severe asthma phenotypes.
- Further research will refine the use of monoclonal antibodies and explore new drug candidates.
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