Up-front neck dissection followed by concurrent chemoradiation in patients with regionally advanced head and neck cancer
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Updated: May 25, 2026
Modified Radical Neck Dissection for Cervical Metastasis
Published on: February 20, 2026
Peter A Paximadis1, Michael E Christensen, Greg Dyson
1Department of Radiation Oncology, Wayne State University/Detroit Medical Center, Detroit, Michigan, USA. ppaximad@med.wayne.edu
Background:
The appropriate management of the neck in patients with regionally advanced head and neck cancer remains controversial. The purpose of this study was to retrospectively analyze our institutional experience with up-front neck dissection followed by definitive chemoradiotherapy.
Methods:
Fifty-five patients with radiographic evidence of large or necrotic lymph nodes underwent up-front neck dissection followed by definitive chemoradiation.
Results:
The 5-year overall survival (OS) and progression-free survival (PFS) rates were estimated at 71.3% and 64.7%, respectively. There were 2 failures in the dissected neck, for a control rate of 96.7%. There were 7 locoregional failures and 12 distant failures, for locoregional and distant control rates of 87.3% and 78.2%, respectively.
Conclusion:
Up-front neck dissection followed by chemoradiotherapy resulted in excellent locoregional control, OS, and PFS. Utilization of this strategy should be considered in carefully selected patients with regionally advanced head and neck cancer. © 2012 Wiley Periodicals, Inc. Head Neck, 2012.
