Related Experiment Video
Updated: May 25, 2026

11:04
Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Total synthesis of (±)-isophellibiline
Raymond L Funk1, Johannes Belmar
1Department of Chemistry, Pennsylvania State University, University Park, PA 16802, USA.
Tetrahedron Letters
|February 7, 2012
Abstract
None:
The total synthesis of (±)-isophellibiline is described. This represents the first synthesis of a member of the nonaromatic homoerythrinan family of alkaloids. The tetracyclic ring system of the natural product was quickly assembled by a strategy that features a retrocycloaddition/cycloaddition reaction of an amidodioxin, an intramolecular Heck reaction and a 6π-electrocyclic ring closure of a dienoic acid.

