Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Dec 31, 2025

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles
05:50

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles

Published on: June 2, 2023

1.7K

Size-dependent cellular toxicity of silver nanoparticles.

Tae-Hyun Kim1, Meeju Kim, Hyung-Seok Park

  • 1Institute of Tissue Regeneration Engineering (ITREN), Dankook University, South Korea.

Journal of Biomedical Materials Research. Part A
|February 7, 2012
PubMed
Summary

Silver nanoparticles (AgNPs) exhibit size-dependent cytotoxicity. Smaller AgNPs induce apoptosis in MC3T3-E1 cells, highlighting the importance of size in biomedical applications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Synergistic protective and regenerative effects of hyaluronic acid and polynucleotides against UVA-induced oxidative stress in dermal fibroblasts.

Scientific reports·2026
Same author

Cell-free therapy for alopecia via the secretome of hiPSC-derived dermal papilla cells.

Journal of tissue engineering·2026
Same author

Sprayable nanozyme hydrogel epigenetically remodels inflammation for diabetic wound regeneration.

Nature communications·2026
Same author

Management of a Complex Medial-End Clavicle Fracture With Hook Plate Fixation After Failed Prior Surgeries: A Case Report and Narrative Review of Surgical Options.

Case reports in orthopedics·2026
Same author

Mechanobiological engineering strategies for oral and maxillofacial tissue regeneration.

Biomaterials·2026
Same author

Modulating cell surface chemistry through mild reduction reinforces extracellular-to-intracellular transmission forces and mechano-signaling.

Materials today. Bio·2026

Area of Science:

  • Nanotechnology
  • Materials Science
  • Toxicology

Background:

  • Silver nanoparticles (AgNPs) are utilized in biomedical materials.
  • Understanding the size-dependent cytotoxicity of AgNPs is crucial but under-researched.

Purpose of the Study:

  • To investigate the impact of AgNP size on cellular toxicity.
  • To evaluate the dose-dependent cytotoxic effects of AgNPs across different cell lines.

Main Methods:

  • Assessed cytotoxicity of ~10, 50, and 100 nm AgNPs against MC3T3-E1 and PC12 cell lines.
  • Measured cell viability, reactive oxygen species (ROS) generation, and lactate dehydrogenase (LDH) release.
  • Analyzed ultrastructural cell morphology and stress-related gene (ho-1, MMP-3) expression.

More Related Videos

Author Spotlight: Advances in Evaluating Human Lung Epithelial Cells' Response to Metal-Organic Frameworks
04:53

Author Spotlight: Advances in Evaluating Human Lung Epithelial Cells' Response to Metal-Organic Frameworks

Published on: May 26, 2023

1.6K
Salinity-dependent Toxicity Assay of Silver Nanocolloids Using Medaka Eggs
06:29

Salinity-dependent Toxicity Assay of Silver Nanocolloids Using Medaka Eggs

Published on: March 18, 2016

8.3K

Related Experiment Videos

Last Updated: Dec 31, 2025

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles
05:50

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles

Published on: June 2, 2023

1.7K
Author Spotlight: Advances in Evaluating Human Lung Epithelial Cells' Response to Metal-Organic Frameworks
04:53

Author Spotlight: Advances in Evaluating Human Lung Epithelial Cells' Response to Metal-Organic Frameworks

Published on: May 26, 2023

1.6K
Salinity-dependent Toxicity Assay of Silver Nanocolloids Using Medaka Eggs
06:29

Salinity-dependent Toxicity Assay of Silver Nanocolloids Using Medaka Eggs

Published on: March 18, 2016

8.3K

Main Results:

  • Cytotoxicity was significantly dependent on both AgNP size and dose.
  • AgNPs induced apoptosis in MC3T3-E1 cells and necrosis in PC12 cells.
  • 10 nm AgNPs showed greater apoptosis induction in MC3T3-E1 cells compared to larger sizes.

Conclusions:

  • AgNP-induced cytotoxic effects on cells are particle size-dependent.
  • Careful consideration of nanoparticle size is essential for safe and effective biomedical applications.