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Related Concept Videos

Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...

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Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
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Bioactive compounds from Carissa spinarum.

Ruchira Wangteeraprasert1, Vimolmas Lipipun, Mekala Gunaratnam

  • 1Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.

Phytotherapy Research : PTR
|February 7, 2012
PubMed
Summary
This summary is machine-generated.

Carissa spinarum L. stems yield compounds with antiherpetic and anticancer potential. The cardiac glycoside evomonoside shows activity against herpes simplex viruses, while certain lignans exhibit cytotoxicity against cancer cells.

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Area of Science:

  • Phytochemistry
  • Pharmacology
  • Natural Products Chemistry

Background:

  • Herbal medicine research seeks novel therapeutic agents.
  • Carissa spinarum L. is explored for its potential bioactivities.

Purpose of the Study:

  • To isolate and identify compounds from Carissa spinarum L. stems.
  • To evaluate the isolated compounds for antiherpetic, cytotoxic, antioxidant, and antibacterial activities.

Main Methods:

  • Phytochemical investigation of Carissa spinarum L. stem extract.
  • Isolation and structural elucidation of 12 compounds (coumarin, cardiac glycosides, lignans).
  • Biological screening including antiherpetic (HSV I/II), cytotoxicity (MCF7, A549), antioxidant (DPPH), and antibacterial assays.

Main Results:

  • Evomonoside, a cardiac glycoside, demonstrated moderate antiherpetic activity against herpes simplex virus types I and II.
  • Three lignans, (-)-carinol, (-)-carissanol, and (-)-nortrachelogenin, displayed cytotoxicity against breast (MCF7) and lung (A549) cancer cell lines.
  • All isolated lignans exhibited moderate anti-DPPH free radical activity.
  • No antibacterial activity was detected for any of the isolated compounds.

Conclusions:

  • Carissa spinarum L. is a source of compounds with significant antiherpetic and cytotoxic properties.
  • Evomonoside is identified as the primary antiherpetic principle from this plant.
  • Specific lignans from Carissa spinarum L. show promise as cytotoxic agents for cancer therapy.