Related Experiment Video
Updated: May 25, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
Published on: May 17, 2024
Early-stage malignant peripheral nerve sheath tumour arising from a solitary neurofibroma
T Hyodo1, Y Sugawara, K Sakayama
1Department of Diagnostic, Ehime University Graduate School of Medicine, Shitsukawa, Toon city, Japan. neneth@m.ehime-u.ac.jp
Abstract:
We report a case of early-stage malignant peripheral nerve sheath tumour (MPNST) found in a solitary neurofibroma, and its CT and MRI findings. A 19-year-old male with no known history of a neurofibromatosis presented with a painless swelling in the left forearm. CT and MRI scans showed a well-circumscribed, intermuscular mass, which was 6.0 cm in diameter and contained a strongly enhanced 1.0 cm nodular structure with surrounding oedema. Peripheral nerve continuity with the mass was not seen. Histological evaluation proved the nodular structure was an MPNST component completely surrounded by neurofibroma. Following an excisional biopsy with wide margins, the patient was followed up for a year without treatment and no recurrence was observed.
More Related Videos
Related Concept Videos
Nervous Tissue: Myelin
Schwann cells begin to form myelin sheaths around axons during fetal development. They wrap around a small...
Peripheral Nervous System: Ganglia and Nerves
Nerves
The nerve is a bundle of axons that serves as the communication highway in the PNS. Each nerve is ensheathed in a protective layer of connective tissue called the epineurium. This outermost layer safeguards the nerve and supports the...

