Related Experiment Video
Updated: May 25, 2026
12:03
Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors
Published on: July 8, 2012
Hematopoietic stem cells: to be or Notch to be
1Program in Cancer Research, Institut Mar Investigacions Mèdiques, Hospital del Mar, Parc de Recerca Biomèdica de Barcelona, Dr Aiguader 88, Barcelona, Spain. abigas@imim.es
Blood
|February 7, 2012
Summary
The Notch pathway is vital for embryonic stem cell generation but less so for adult stem cells. This review details Notch
Area of Science:
- Developmental Biology
- Stem Cell Biology
- Cell Signaling
Background:
- The Notch signaling pathway is conserved and critical for cell fate determination.
- It mediates cell-cell interactions essential for generating cell diversity.
- Notch promotes T-cell differentiation in adult hematopoiesis, obscuring roles in other lineages.
Purpose of the Study:
- To review the role of the Notch pathway in hematopoietic stem cell (HSC) ontology.
- To explore Notch's function across embryonic, fetal, and adult HSC stages.
- To examine Notch's regulation of stem cell capacities in other systems.
Main Methods:
- Literature review of recent research on Notch signaling and stem cells.
- Synthesis of findings on Notch's role in HSC development and maintenance.
- Comparative analysis of Notch function in various stem cell systems.
Main Results:
- Notch is essential for embryonic HSC generation.
- Adult HSCs are largely refractory to Notch intervention in experimental settings.
- Emerging evidence reveals Notch's influence on additional blood lineages.
Conclusions:
- The Notch pathway plays distinct roles in HSC development versus adult maintenance.
- Understanding Notch's multifaceted roles is key to stem cell biology.
- Further research is needed to fully elucidate Notch's impact on diverse stem cell functions.
More Related Videos
11:06Combining Intravital Fluorescent Microscopy (IVFM) with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches
Published on: March 21, 2017
14:37Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
Published on: November 1, 2017
Related Concept Videos
01:01Regulation of Hematopoietic Stem Cells
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
01:19Multipotency of Hematopoietic Stem Cells
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
01:12Role Of Notch Signalling In Intestinal Stem Cell Renewal
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
01:21Hematopoiesis
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...