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Updated: Aug 4, 2026

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
Published on: September 12, 2016
Serial studies of evoked potentials and circulating lymphocyte subsets for multiple sclerosis: attempts to monitor
H M Chapel1, M Small, S Gregory
1Department of Immunology, John Radcliffe Hospital, Oxford, UK.
Abstract:
A concurrent change in evoked potential measurements and quantitation of circulating T-suppressor (CD8) lymphocyte subpopulations might indicate increased subclinical disease activity. Eight untreated patients with clinically definite multiple sclerosis were monitored monthly for changes in the numbers of cells positive for CD8 markers, and hence in the ratio of CD4: CD8 positive cells. Such changes were found not to be associated with changes in evoked potentials or clinical status.
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