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[Percutaneous permeability study for patches Shangshi Zhitong on different kinds of bases]
Xiaoping Yan1, Shijie Guan, Rui Zheng
1Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Objective:
To study the percutaneous permeability of patches Shangshi Zhitong on different kinds of bases with the permeation percentage of brucine, strychnine and atropine.
Method:
Using modified Franz difusion to investigate the penetration quantity of brucine, strychnine and atropine. The contents of brucine, strychnine and atropine were determined by HPLC.
Result:
The average accumulative permeation percentage of brucine, strychnine and atropine on new base were 53.25%, 74.52% were 34.32%, respectively, and on old base are 54.90%, 50.24%, 46. 54%, respectively.
Conclusion:
The new base benefits the lipophilic drugs and releases more stably.
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