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Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
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[Flavonoids from Artocarpus hypargyreus].

Xin Qiao1, Ting Zhao, Meng Wang

  • 1School of Pharmacy, Fudan University, Shanghai 201203, China.

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica
|February 8, 2012
PubMed
Summary
This summary is machine-generated.

Researchers identified ten flavonoids from Artocarpus hypargyreus, including a new isoprenylated flavone. Several compounds were reported from this plant for the first time, expanding knowledge of its chemical constituents.

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Area of Science:

  • Phytochemistry
  • Natural Products Chemistry

Context:

  • Artocarpus hypargyreus is a plant species known for its diverse secondary metabolites.
  • Flavonoids are a class of plant compounds with various biological activities.

Purpose:

  • To isolate and characterize flavonoid compounds from Artocarpus hypargyreus.
  • To identify novel flavonoid structures and compounds previously unreported in this species.

Summary:

  • Ten compounds were isolated from Artocarpus hypargyreus using chromatographic and spectroscopic techniques.
  • The identified compounds include artohypaflavone (a new isoprenylated flavone), brosimone H, artonin A, artocarpin, artopetelin B, (-)-epiafzelechin, oxyresveratrol, (+)-afzelechin, (+)-catechin, and (+)-afzelechin-3-O-alpha-L-rhamnopyranoside.
  • Compounds 2, 4-6, and 8 represent new discoveries for this plant species.

Impact:

  • Contributes to the chemotaxonomic understanding of the Artocarpus genus.
  • Provides a basis for further investigation into the potential biological activities of these isolated flavonoids.
  • Highlights Artocarpus hypargyreus as a source of novel and diverse flavonoid compounds.