[Dependence of IgG titers specific to various hepatitis C virus proteins on features of chronic infection course]
Related Experiment Video
Updated: May 25, 2026

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix
Published on: October 20, 2021
Aim:
Analysis of IgG titers that are specific to various hepatitis C proteins depending on features of chronic infection course.
Materials And Methods:
Qualitative analysis of levels of IgG specific to a number of hepatitis C virus proteins was performed in 30 patients and 30 virus carriers.
Results:
Significant differences between these HCV infection course variants by level of accumulation of all studied HCV antibody groups were detected. Low a-core and a-NS4 IgG, high a-NS3 and medium a-NS5 titers may be an indicator of HCV carriage. Medium and high a-core, medium a-NS3 and a-NS4 as well as higher a-NS5 titers indicate chronic hepatitis C.
Conclusion:
The proposed method can be used for screening of chronic HCV infection course in the clinical practice.
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