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Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
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Synthesis and biological properties of highly sequence-specific-alkylating N-methylpyrrole-N-methylimidazole

Gengo Kashiwazaki1, Toshikazu Bando, Tomofumi Yoshidome

  • 1Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan.

Journal of Medicinal Chemistry
|February 8, 2012
PubMed

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Azide ions act as good nucleophiles and react with unhindered alkyl halides to form alkyl azides. Alkyl azides do not participate in further nucleophilic substitution reactions, thereby eliminating the chances of polyalkylated products. Alkyl azides are reduced by hydride-based reducing agents, like lithium aluminum...
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Basicity of Heterocyclic Aromatic Amines

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