Related Experiment Video
Updated: May 25, 2026
05:31
Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
Published on: January 26, 2024
Periodontitis as a risk factor for preeclampsia.
Genivaldo Moura da Silva1, Sonia B Coutinho, Maria Dilma B V Piscoya
1Department of Maternal and Child Health, Universidade de Pernambuco, Recife, Brazil. mouralibia@oi.com.br
Journal of Periodontology
|February 8, 2012
Summary
Periodontitis, an inflammatory gum condition, significantly increases the risk of developing preeclampsia. This study confirms periodontitis as an independent risk factor for preeclampsia in the studied population.
Area of Science:
- Oral Health
- Obstetrics
- Public Health
Background:
- Periodontitis involves inflammation and destruction of tooth-supporting tissues and alveolar bone.
- Infection is a known factor in preeclampsia etiology, suggesting a link between periodontitis and preeclampsia.
- Previous research has considered periodontitis a potential risk factor for preeclampsia.
Purpose of the Study:
- To determine if periodontitis is a risk factor for preeclampsia.
- To identify other potential risk factors associated with preeclampsia.
Main Methods:
- A case-control study involving 574 women post-childbirth was conducted.
- Data included biologic, socioeconomic, medical, and dental records, with periodontal examinations for probing depth and gingival recession.
- Multivariate logistic regression analysis was used to assess the association between periodontitis and preeclampsia, adjusting for confounding variables.
Main Results:
- Periodontitis was identified as an independent risk factor for preeclampsia.
- Adjusted odds ratio (OR) for periodontitis as a risk factor was 8.60 (CI: 3.92-18.88, P < 0.001).
- Using the CDC/AAP definition, the adjusted OR was 2.03 (95% CI: 1.43-2.90, P < 0.001).
Conclusions:
- Periodontitis is a significant risk factor for preeclampsia in the population studied.
- The findings highlight the importance of oral health in pregnancy outcomes.
- Further research may explore causal mechanisms and preventive strategies.
Related Concept Videos
01:28Development of the Oral Microbiota
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
01:20Pathophysiology of Diabetes
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
01:22Diabetes Mellitus: Type 2 and Gestational
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
01:27The Oral Microbiota
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
01:33Hormonal Regulation
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
01:27Diabetic Retinopathy
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...