Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hippocampal representation in place learning.

H Eichenbaum1, C Stewart, R G Morris

  • 1Department of Biological Sciences, Wellesley College, Massachusetts 02181.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|November 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cumulative effective dose among 5.6 million CT exams in a multinational radiation dose registry.

The British journal of radiology·2026
Same author

Rapid earthquake magnitude classification via P-wave strains from borehole strainmeters and Distributed Acoustic Sensing.

Nature communications·2026
Same author

Commercial Impacts on Assisted Reproductive Technology: A Scoping Review.

Journal of bioethical inquiry·2025
Same author

On the backseat: Analyzing motorcycle passenger injuries in children.

American journal of surgery·2025
Same author

Evaluating the use of electromyography in UK and European gait laboratories for the assessment of cerebral palsy and other neurological and musculoskeletal conditions.

Gait & posture·2024
Same author

The Fragility of Scientific Rigour and Integrity in "Sped up Science": Research Misconduct, Bias, and Hype and in the COVID-19 Pandemic.

Journal of bioethical inquiry·2023
Same journal

Endogenous peptide derived from c-Cbl-associated protein counteracts its inhibitory effect on enteric neural crest cell colonization in Hirschsprung disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Drowsiness alters the neural dynamics but not the core computations of multisensory integration.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

A Matter of Parameters: Tailored Transcranial Focused Ultrasound Enhances Cortico-Thalamo-Cortical Circuit Resonance.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Proactive visual and motor prioritization differentially scale with cue reliability.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Erratum: Yao et al., "Estrogen Regulates Bcl-w and Bim Expression: Role in Protection against β-Amyloid Peptide-Induced Neuronal Death".

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Erratum: L'Episcopo et al., "Plasticity of Subventricular Zone Neuroprogenitors in MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine) Mouse Model of Parkinson's Disease Involves Cross Talk between Inflammatory and Wnt/β-Catenin Signaling Pathways: Functional Consequences for Neuroprotection and Repair".

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
See all related articles

Damage to the hippocampal system impairs flexible spatial learning, not all place learning. Fornix-lesioned rats showed deficits in adapting learned routes when cues or starting positions changed.

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Animal Behavior

Background:

  • The hippocampal system is crucial for spatial learning and memory.
  • Previous studies suggest fornix lesions cause general place-learning impairments.

Purpose of the Study:

  • To investigate if hippocampal system damage universally impairs place learning.
  • To examine the flexibility of spatial representations after fornix lesions.

Main Methods:

  • Rats with fornix lesions (FX rats) and normal rats were trained on a water maze task requiring association of escape location with a specific route.
  • Performance was assessed using escape latencies and various probe tests involving altered cues or starting positions.

Main Results:

Related Experiment Videos

  • Both groups acquired the task, with FX rats showing slightly slower initial learning.
  • FX rats' performance was similar to controls in standard testing but inflexible when cues or starting positions were altered.
  • Probe tests revealed FX rats relied on a less adaptable spatial representation compared to normal rats.

    • Conclusions:

    • Hippocampal system damage impairs the flexible use of spatial information, not all place learning.
    • The nature of the learning deficit depends on the representational demands of the task.
    • Fundamental procedural learning is spared, but flexible application of learned spatial information is compromised.