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Updated: May 25, 2026

Guidelines for Elective Pediatric Fiberoptic Intubation
Published on: January 17, 2011
An optimum time for intravenous cannulation after induction with sevoflurane in children
Ashutosh Joshi1, Sumin Lee, Dilip Pawar
1Department of Paediatric Anaesthesia, KK Women's and Children's Hospital, Singapore. 09ashutosh@gmail.com
Insights
For safe intravenous cannulation in children after sevoflurane induction, wait 3.5 minutes after loss of eyelash reflex. This ensures successful IV placement without movement or airway issues.
Area of Science:
- Anesthesiology
- Pediatric Anesthesia
Background:
- Inhalational induction with sevoflurane is common in pediatric anesthesia.
- Optimal timing for subsequent intravenous cannulation after sevoflurane induction is not well-established.
Purpose of the Study:
- To determine the safe and optimal time for intravenous cannulation following sevoflurane inhalational induction in pediatric patients.
Main Methods:
- The study involved pediatric patients aged 4-10 years undergoing sevoflurane induction.
- The up-and-down method with 30-second increments was used to determine cannulation time.
- Successful cannulation was defined as no movement, coughing, or laryngospasm.
Main Results:
- The estimated time for effective intravenous cannulation in 50% of patients was 1.90 minutes.
- The time for effective cannulation in 95% of patients was determined to be 3.32 minutes.
Conclusions:
- An optimal waiting time of 3.5 minutes after loss of eyelash reflex is recommended for intravenous cannulation.
- This timing aims to ensure successful and safe IV access post-sevoflurane induction in children.
Background:
It is a common practice to perform inhalational induction with sevoflurane followed by intravenous cannulation in children. However, there is little information regarding the time at which the intravenous cannulation can be attempted safely after sevoflurane induction.
Aim:
To determine the optimal time for safe intravenous cannulation in children induced with sevoflurane.
Methods:
Pediatric patients aged 4-10 years receiving sevoflurane inhalational induction for elective cases were recruited. General anesthesia was induced with sevoflurane and oxygen via mask, then intravenous cannulation was attempted. The time for intravenous cannulation was determined by the use of up-and-down method using 30 s as a step size. Intravenous cannulation without any movement, coughing, or laryngospasm was considered successful. The up-and-down sequences were analyzed by the probit test.
Results:
The time for effective intravenous cannulation in 50% patients was 1.90 min (95% confidence limits, 1.24-2.41 min). The time for effective cannulation in 95% of patient population was 3.32 min (95% confidence limits, 2.68-6.77 min).
Conclusion:
We recommend an optimal time of 3.5 min for attempting intravenous cannulation after the loss of eyelash reflex with sevoflurane induction.
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