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Cytomegalovirus Disease

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Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...

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Related Experiment Video

Updated: May 25, 2026

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates

Published on: July 6, 2013

Vaccines for cytomegalovirus.

D I Bernstein¹

¹David.Bernstein@cchmc.org

Infectious Disorders Drug Targets

|February 8, 2012

Summary

This summary is machine-generated.

Developing a Cytomegalovirus (CMV) vaccine is crucial for preventing congenital infections. Recent trials show promise with subunit glycoprotein B vaccines, though optimal composition is still under investigation.

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Last Updated: May 25, 2026

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Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus

Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus

Published on: May 7, 2012

Area of Science:

Virology
Immunology
Vaccinology

Background:

Cytomegalovirus (CMV) is a primary cause of congenital infections globally.
Developing an effective CMV vaccine is a significant public health priority.
Previous vaccine candidates, like the live attenuated Towne vaccine, have shown limited efficacy.

Purpose of the Study:

To review the progress and challenges in developing a vaccine against Cytomegalovirus.
To evaluate different vaccine strategies and their potential for preventing CMV infection and transmission.

Main Methods:

Review of historical and recent clinical trial data for CMV vaccines.
Analysis of various vaccine platforms including live attenuated, subunit, replicon, and DNA vaccines.
Examination of vaccine components such as glycoprotein B (gB), phosphoprotein (pp)65, and Immediate Early (IE)1 antigens.

Main Results:

A subunit glycoprotein B (gB) vaccine with MF59 adjuvant demonstrated a reduction in CMV infections in a trial with postpartum women.
Early CMV vaccine trials using the Towne vaccine showed inconsistent protection.
Multiple vaccine approaches, including replicons and DNA vaccines, are in clinical trials.

Conclusions:

Recent advances, particularly with gB-based vaccines, offer optimism for developing a protective CMV vaccine.
The optimal formulation and composition for a CMV vaccine are still being determined.
Ongoing clinical trials continue to explore various CMV vaccine candidates.