Related Experiment Video
Updated: May 25, 2026
05:53
Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
Published on: July 6, 2013
Vaccines for cytomegalovirus.
1David.Bernstein@cchmc.org
Infectious Disorders Drug Targets
|February 8, 2012
Summary
Developing a Cytomegalovirus (CMV) vaccine is crucial for preventing congenital infections. Recent trials show promise with subunit glycoprotein B vaccines, though optimal composition is still under investigation.
Area of Science:
- Virology
- Immunology
- Vaccinology
Background:
- Cytomegalovirus (CMV) is a primary cause of congenital infections globally.
- Developing an effective CMV vaccine is a significant public health priority.
- Previous vaccine candidates, like the live attenuated Towne vaccine, have shown limited efficacy.
Purpose of the Study:
- To review the progress and challenges in developing a vaccine against Cytomegalovirus.
- To evaluate different vaccine strategies and their potential for preventing CMV infection and transmission.
Main Methods:
- Review of historical and recent clinical trial data for CMV vaccines.
- Analysis of various vaccine platforms including live attenuated, subunit, replicon, and DNA vaccines.
- Examination of vaccine components such as glycoprotein B (gB), phosphoprotein (pp)65, and Immediate Early (IE)1 antigens.
Main Results:
- A subunit glycoprotein B (gB) vaccine with MF59 adjuvant demonstrated a reduction in CMV infections in a trial with postpartum women.
- Early CMV vaccine trials using the Towne vaccine showed inconsistent protection.
- Multiple vaccine approaches, including replicons and DNA vaccines, are in clinical trials.
Conclusions:
- Recent advances, particularly with gB-based vaccines, offer optimism for developing a protective CMV vaccine.
- The optimal formulation and composition for a CMV vaccine are still being determined.
- Ongoing clinical trials continue to explore various CMV vaccine candidates.
More Related Videos
08:08qPCR Is a Sensitive and Rapid Method for Detection of Cytomegaloviral DNA in Formalin-fixed, Paraffin-embedded Biopsy Tissue
Published on: July 9, 2014
11:18Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus
Published on: May 7, 2012
Related Concept Videos
01:27Cytomegalovirus Disease
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
01:51Vaccinations
Overview
01:25Immunodeficiency Diseases
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
There are three main causes of immunodeficiency disorders...
01:01Hypersensitivity Reactions: Cytolytic Reactions
Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...
01:29Microorganisms in Medicine and Therapeutics
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
01:30Cancer Vaccines
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...