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Related Experiment Video

Updated: May 25, 2026

Measuring and Modeling Contractile Drying in Human Stratum Corneum
08:00

Measuring and Modeling Contractile Drying in Human Stratum Corneum

Published on: March 1, 2017

Two dimensional finite element modelling for dynamic water diffusion through stratum corneum.

Perry Xiao1, Robert E Imhof

  • 1Photophysics Research Centre, London South Bank University, 103 Borough Road, London SE1 0AA, UK. xiaop@lsbu.ac.uk

International Journal of Pharmaceutics
|February 8, 2012
PubMed
Summary
This summary is machine-generated.

This study models water diffusion through human stratum corneum (SC), revealing both intercellular and transcellular routes are vital. Larger corneocyte size reduces trans-epidermal water loss (TEWL), impacting topical drug delivery.

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Area of Science:

  • Dermatology and Pharmaceutical Sciences
  • Computational Biology and Biophysics

Background:

  • Understanding solvent penetration through the stratum corneum (SC) is crucial for transdermal drug delivery.
  • The relative importance of intercellular versus transcellular routes for diffusion across the SC remains debated.

Purpose of the Study:

  • To develop a 2D finite element model simulating dynamic water diffusion through the SC.
  • To investigate the contributions of intercellular and transcellular pathways to water transport.
  • To explore factors influencing trans-epidermal water loss (TEWL).

Main Methods:

  • A two-dimensional finite element model based on the SC's brick-and-mortar structure (corneocytes and lipids).
  • Simulation of dynamic water diffusion under defined initial and boundary conditions.
  • Analysis of diffusion flux, corneocyte size, SC thickness, and environmental factors.

Main Results:

  • Both intercellular and transcellular routes significantly contribute to water diffusion.
  • Despite higher flux rates in intercellular routes, transcellular diffusion dominates due to corneocyte area.
  • Trans-epidermal water loss (TEWL) is inversely proportional to corneocyte size.

Conclusions:

  • The model provides insights into water diffusion dynamics within the SC, applicable to other topical substances.
  • Corneocyte size is a key determinant of TEWL, with larger cells reducing water loss.
  • SC thickness, external conditions, and diffusion coefficients also influence water transport and TEWL.