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Solifenacin for overactive bladder: a systematic review and meta-analysis.
Deyi Luo1, Liangren Liu, Ping Han
1Department of Urology, West China Hospital, Sichuan University, Guoxue Xiang #37, Chengdu, Sichuan 610041, People's Republic of China.
International Urogynecology Journal
|February 8, 2012
Summary
Solifenacin effectively treats overactive bladder symptoms like urgency and incontinence. The 5 mg dose is recommended for its balance of efficacy and tolerable side effects, such as constipation and blurred vision.
Area of Science:
- Pharmacology
- Urology
Background:
- Overactive bladder (OAB) is a common condition characterized by urinary urgency.
- Current treatments aim to improve quality of life by managing OAB symptoms.
Purpose of the Study:
- To evaluate the efficacy and safety of solifenacin for overactive bladder treatment.
- To compare solifenacin with placebo and tolterodine through a meta-analysis of randomized controlled trials (RCTs).
Main Methods:
- Systematic review and meta-analysis of nine RCTs.
- Data extracted and assessed using a predefined protocol.
- Study quality evaluated with the Jadad score; heterogeneity assessed using the chi-squared test.
Main Results:
- Solifenacin significantly reduced urgency, micturition, and incontinence episodes compared to placebo and tolterodine.
- Solifenacin 10 mg showed greater efficacy than 5 mg for reducing micturitions.
- Higher rates of constipation and blurred vision were observed with solifenacin versus tolterodine, though overall adverse event incidence was similar.
Conclusions:
- Solifenacin is an effective treatment for overactive bladder, comparable in efficacy to tolterodine.
- Solifenacin 5 mg offers a favorable balance of efficacy and tolerability.
- Adverse effects like constipation and blurred vision warrant consideration in clinical practice.
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