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Updated: May 25, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
03:26

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Published on: August 28, 2020

Pathophysiology of overactive bladder.

Mai A Banakhar1, Tariq F Al-Shaiji, Magdy M Hassouna

  • 1Toronto Western Hospital, Toronto, ON, M5T2S8, Canada. drmaibanakher@hotmail.com

International Urogynecology Journal
|February 8, 2012
PubMed
Summary
This summary is machine-generated.

Overactive bladder (OAB) significantly impacts quality of life and healthcare costs. This review explores current theories on the causes of OAB, including neurogenic, myogenic, and idiopathic factors.

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Last Updated: May 25, 2026

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A Decentralized (Ex Vivo) Murine Bladder Model with the Detrusor Muscle Removed for Direct Access to the Suburothelium during Bladder Filling
06:36

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Published on: November 28, 2019

Area of Science:

  • Urology
  • Pathophysiology

Background:

  • Overactive bladder (OAB) is a prevalent condition affecting patient quality of life and incurring substantial socioeconomic costs.
  • OAB is clinically defined by urinary urgency, often accompanied by frequency and nocturia, excluding urinary tract infections.

Purpose of the Study:

  • To review and synthesize contemporary theories regarding the pathophysiology of overactive bladder.

Main Methods:

  • Literature review of current scientific theories on OAB pathophysiology.
  • Analysis of neurogenic, myogenic, and idiopathic contributing factors.

Main Results:

  • Pathophysiology of OAB is multifactorial, involving complex interactions.
  • Key theories encompass neurological dysfunction, smooth muscle abnormalities, and idiopathic origins.

Conclusions:

  • Understanding the diverse pathophysiological mechanisms of OAB is crucial for developing targeted therapies.
  • Further research into these mechanisms can lead to improved patient outcomes and reduced disease burden.