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Jun activation domain-binding protein 1 expression in oral squamous cell carcinomas inversely correlates with the

Ling Gao1, Shuo Huang, Wenhao Ren

  • 1Department of Oral Maxillofacial Surgery, Stomatological Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, People's Republic of China.

Medical Oncology (Northwood, London, England)
|February 8, 2012
PubMed

Insights

Jun activation domain-binding protein 1 (Jab1) overexpression correlates with poor prognosis in oral squamous cell carcinoma (OSCC). Jab1 may degrade p27, suggesting Jab1 as a potential therapeutic target for OSCC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Jun activation domain-binding protein 1 (Jab1) is a potential regulator of cyclin-dependent kinase inhibitor p27 degradation.
  • The precise role of Jab1 in oral squamous cell carcinoma (OSCC) pathogenesis remains unclear.

Purpose of the Study:

  • To investigate Jab1 and p27 expression levels in OSCC and normal oral mucosa.
  • To evaluate the correlation between Jab1 expression and p27 protein levels.
  • To determine the clinical relevance of Jab1 expression in OSCC prognosis.

Main Methods:

  • Immunohistochemical analysis of Jab1 and p27 expression in 206 OSCC specimens and normal oral mucosa.
  • Correlation analysis between Jab1 and p27 expression levels.
  • Kaplan-Meier survival analysis to assess the association with patient prognosis.

Main Results:

  • Jab1 was overexpressed in 83% of OSCCs compared to 19% in normal oral mucosa.
  • p27 expression was observed in 60% of OSCCs.
  • A significant inverse correlation was found between Jab1 and p27 expression (P<0.001).
  • Jab1 overexpression and low p27 expression were significantly associated with poor patient prognosis.

Conclusions:

  • Jab1 overexpression is inversely correlated with p27 expression in OSCC.
  • Jab1 may contribute to OSCC pathogenesis by promoting p27 degradation.
  • Jab1 represents a potential therapeutic target for OSCC.

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