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Autonomic nervous system function in rheumatoid arthritis.

Miroslav Vlcek¹, Jozef Rovensky, Graeme Eisenhofer

¹Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia. miroslav.vlcek@savba.sk

Cellular and Molecular Neurobiology

|February 8, 2012

Summary

Rheumatoid arthritis (RA) patients under 40 showed normal sympathoneural and adrenomedullary system responses during orthostatic challenges. This suggests these systems are not impaired in younger RA individuals.

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Area of Science:

Immunology
Neuroscience
Cardiovascular Physiology

Background:

The sympathoneural and adrenomedullary systems play a role in immune regulation.
Impairment of these systems has been hypothesized in rheumatoid arthritis (RA).

Purpose of the Study:

To evaluate sympathetic response to orthostasis in young female RA patients.
To compare autonomic nervous system activity between RA patients and healthy controls.

Main Methods:

Assessed plasma epinephrine and norepinephrine levels.
Analyzed heart rate variability (HRV) for sympathoneural activity.
Measured blood pressure and electrocardiogram during orthostatic testing in 22 RA females (<40 years) and 15 controls.

Main Results:

RA patients and controls exhibited similar plasma epinephrine and norepinephrine levels.
Blood pressure response to orthostasis was comparable between groups.
Heart rate and HRV parameters did not differ between RA patients and controls.

Conclusions:

Younger RA patients (<40 years) demonstrate normal sympathoneural and adrenomedullary system reactivity during orthostatic challenges.
Autonomic nervous system function appears preserved in this demographic of RA patients.