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Uric acid and IGF1 as possible determinants of FGF23 metabolism in children with normal renal function

Justine Bacchetta1, Pierre Cochat, Isidro B Salusky

  • 1Centre de Référence des Maladies Rénales Rares, Service de Néphrologie et Rhumatologie Pédiatriques, Hôpital Femme Mère Enfant, 59 Bd Pinel, 69677, Bron, France. j.bacchetta@laposte.net

Pediatric Nephrology (Berlin, Germany)
|February 8, 2012
PubMed

Insights

Fibroblast growth factor 23 (FGF23) may indicate nutritional status in children with normal kidney function. FGF23 levels correlate with uric acid, phosphorus, and insulin growth factor 1 (IGF1), suggesting a link to diet and growth.

Area of Science:

  • Pediatric Endocrinology
  • Nephrology
  • Nutritional Science

Background:

  • Fibroblast growth factor 23 (FGF23) is a key hormone regulating phosphate and vitamin D metabolism.
  • Elevated FGF23 is observed in early chronic kidney disease (CKD).
  • The relationship between FGF23, growth, and nutrition in children with normal kidney function remains unclear.

Purpose of the Study:

  • To investigate the interplay between FGF23 levels and nutritional/growth biomarkers in children with preserved renal function.
  • To identify predictors of FGF23 levels in this pediatric population.

Main Methods:

  • Secondary analysis of the cross-sectional observational INU23 study.
  • Included 98 children with normal renal function (GFR > 100 ml/min/1.73 m²).
  • Bivariate and multivariable analyses were used to assess associations.

Main Results:

  • C-terminal FGF23 correlated positively with phosphorus and uric acid.
  • Intact FGF23 correlated positively with uric acid, insulin growth factor 1 (IGF1), age, BMI, and 25-hydroxyvitamin D (25(OH)D).
  • Independent predictors of C-terminal FGF23 were 25(OH)D, uric acid, and phosphorus; for intact FGF23, they were 25(OH)D, uric acid, and IGF1.

Conclusions:

  • FGF23 may serve as an early nutritional indicator in children with normal kidney function, reflecting high protein and phosphate intake.
  • The association between FGF23 and IGF1 suggests a potential link between FGF23 and growth, requiring further research.
Abstract

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