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Related Experiment Video

Updated: May 25, 2026

Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction
14:19

Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction

Published on: October 14, 2016

Measuring myocardial salvage.

Hans Erik Bøtker1, Anne Kjer Kaltoft, Steen Fjord Pedersen

  • 1Department of Cardiology, Aarhus University Hospital Skejby, Aarhus N, Denmark. heb@dadlnet.dk

Cardiovascular Research
|February 8, 2012
PubMed
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Cardiovascular magnetic resonance (CMR) offers a promising, single-session method for assessing myocardial salvage, a key indicator of heart attack treatment effectiveness. This technique accurately quantifies both the area at risk and final infarct size, surpassing limitations of other methods.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Cardiovascular Research

Background:

  • Myocardial salvage quantifies cardioprotective therapy efficacy.
  • Area at risk (AAR) and final infarct size (FIS) determine salvage.
  • Current methods for AAR and FIS quantification have limitations.

Purpose of the Study:

  • To evaluate cardiovascular magnetic resonance (CMR) as a comprehensive technique for assessing myocardial salvage.
  • To compare CMR with existing methods like single-photon emission tomography (SPECT).

Main Methods:

  • Review of existing literature on AAR and FIS quantification.
  • Analysis of CMR techniques including T1/T2-weighted imaging, early and late gadolinium enhancement.
  • Comparison of CMR's accuracy, logistical feasibility, and radiation exposure against SPECT.

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Last Updated: May 25, 2026

Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction
14:19

Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction

Published on: October 14, 2016

Intramyocardial Transplantation of MSC-Loading Injectable Hydrogels after Myocardial Infarction in a Murine Model
09:19

Intramyocardial Transplantation of MSC-Loading Injectable Hydrogels after Myocardial Infarction in a Murine Model

Published on: September 20, 2020

Main Results:

  • CMR can assess myocardial oedema for AAR and late gadolinium enhancement for FIS in a single examination.
  • CMR offers high spatial resolution and potential for retrospective quantification.
  • SPECT is validated but logistically challenging, expensive, and involves radiation.

Conclusions:

  • CMR is the most appropriate technique for myocardial salvage assessment due to its comprehensive capabilities.
  • Further definition of optimal CMR protocols for AAR assessment is needed.
  • A comprehensive CMR protocol is recommended for reliable myocardial salvage assessment.